Topical Researches - Treatment and Rehabilitation
Can Uncaria rhynchophylla alleviate damages produced by ketamine? (2020)

Researcher: Prof. YEW Tai Wai David, Hong Kong College of Technology

Background: Studies of the central nervous system demonstrated that uncaria rhynchophylla (Gouteng) interaction with ketamine appeared to improve the consolidated memory of the mice and downregulate the number of dead cells in regions of the central nervous system induced by ketamine.

Aims: To perform experiments on animal models so as to investigate the effect of Gouteng as a potential therapeutic intervention for ketamine damage, or whether it could replace ketamine as another abuse agent, and provided evidence for the underlying mechanism of effect of Gouteng on the central nervous system.

Method: Methods employed included behavioral, biochemical, immunohistochemical and histopathological studies. Toxic effects of ketamine on the liver and heart were studied via observation on histopathology and electrocardiogram (for heart).

Results and Conclusion: Gouteng showed promise as an adjunct treatment on the toxicity created by ketamine. However, it was important to note that, Gouteng, like any medicine, the long-term usage of which will lead to increase of serum transaminase and creatinine levels. Proper supervision and advice by a Chinese medicine practitioner and/or a medical practitioner in Western medicine was a must for human ketamine patients.

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Substance Abuse Rehabilitation in a Therapeutic Community: A Multiwave, Cross-Sequential, Mixed Methods Study of Christian Zheng Sheng College (2019)

Researcher: Dr. Chan, Christian Shaunlyn, The University of Hong Kong
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